SEMAGLUTIDE SUBLINGUAL

There is a growing demand worldwide for glucagonlike peptide (GLP)-1 agonists, a class of medications utilized in the treatment of type 2 diabetes and obesity. Semaglutide, the active ingredient in the injectable medications Ozempic® and Wegovy® , is the most popular GLP-1 agonist and there are often shortages in the marketplace [1].  Many patients would prefer to avoid injections if possible, and there is an extremely low absorption of the oral tablets (less than 1% per the labeling for Rybelsus®). For these reasons, prescribers and patients may prefer a patent-pending compounded formulation of semaglutide for sublingual administration comprising Rybelsus tablets and SubMagna SL HMW [2]. SubMagna is an anhydrous, self-emulsifying drug delivery system intentionally developed to carry drugs of high molecular weight (HMW) in a sublingual route of administration. This innovative compounding base also benefits from mucoadhesive properties which increase the contact time of the drug in the sublingual space [3]. Please see the video below for counseling on how to use your semaglutide sublingual medication.

Important Counseling Points for Sublingual Semaglutide

SEMAGLUTIDE SUBLINGUAL COUNSELING

·         MAKE SURE TO SHAKE UP THE AMBER BOTTLE BEFORE EACH DAILY DOSE.

·         PLACE CONTENTS UNDER TONGUE AND HOLD FOR AT LEAST 2 MINUTES,THEN SWALLOW REMAINDER.

·         DO NOT EAT OR DRINK FOR AT LEAST 30 MINUTES.

·         STORE AT ROOM TEMPERATURE.